"Functional genomics and genetic risk profiling to enhance our understanding of Alzheimer's Disease etiology and progression"

This grand round has already taken place.

Neurology Grand Rounds: In-Person with Hybrid Option

In-Person Location: BRT 115: 460 W 12th Ave, Columbus, OH 43210 (refreshments provided)

Virtual Information:
Join Zoom Meeting
https://osu.zoom.us/j/97601242494?pwd=ZkhJdkpVTnRPSUtkUkJiNWFmc0Fldz09
Meeting ID: 976 0124 2494
Password: 771557

Can't make it this time or want to see more? Check out our schedule for the upcoming year here

About the Speaker:

Dr. Oscar Harari is the Helen C. Kurtz Associate Professor of Neurology, Director of the Division of Neurogenetics at the Department of Neurology at The Ohio State University. Dr. Harari's research focuses on the biological mechanisms underlying neurological disorders, with a particular emphasis on Alzheimer's disease and other forms of dementia.

Dr. Harari's research bridges the fields of data science, bioinformatics, and human genomics. He leads a multidisciplinary team that leverages high-dimensional genomic data, including single-cell and spatially resolved transcriptomics, to study neurodegeneration and improve the understanding of complex disease biology. His research focuses on genetic and functional genomic studies of Alzheimer's disease and related dementias. His group combines omics approaches from postmortem human brains with the latest experimental models to provide better insights into the mechanisms by which coding and non-coding variants associated with the disease mediate risk. Specifically, he examines the impact of the neurovascular unit in Alzheimer's, studies autosomal dominant forms of the disease (with mutations in APP, PSEN1, and PSEN2), investigates sex differences, and explores Alzheimer's molecular heterogeneity. All these efforts aim to identify novel biomarkers and therapeutic treatments to enable precision medicine approaches for neurodegeneration.

Dr. Harari serves on the Executive Committee of the Alzheimer's Disease Sequencing Project – Functional Genomics and regularly reviews for NIH study sections and journals. He has established multiple collaborative partnerships with groups at Ohio State University as well as national and international institutions to support his research efforts. Dr. Harari's work has been generously funded by the National Institute on Aging, the Archer Fund, and the Chan Zuckerberg Initiative.

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Please contact the Grand Round coordinator listed below:

Maggie Sullivan
Department: Neurology
Phone: (614) 814-0460
Email: margaret.sullivan@osumc.edu